Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation[S]
ABCA1 plays a major role in HDL metabolism.Cholesterol secretion by ABCA1 is dependent on the presence of extracellular acceptors, such as lipid-free apolipoprotein A-I (apoA-I).However, the importance of the direct interaction between apoA-I and ABCA1 in HDL formation remains unclear.In contrast, ABCB4 mediates the secretion of phospholipids and c